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The anticonvulsant effect of phencyclidine in rats

✍ Scribed by E. B. Geller; L. H. Adler; C. Wojno; M. W. Adler

Publisher: Springer
Year: 1981
Tongue: English
Weight: 171 KB
Volume: 74
Category: Article
ISSN: 0033-3158
DOI: 10.1007/bf00431765

No coin nor oath required. For personal study only.

✦ Synopsis

Phencyclidine hydrochloride (PCP), injected subcutaneously into rats 30 rain before exposure to the chemical convulsant flurothyl, raised seizure thresholds in a doserelated manner. The narcotic antagonist naloxone was ineffective in blocking the PCP-induced effect. This anticonvulsant property of PCP is like that previously reported for the narcotic agonist-antagonists cyclazocine and SKF 10,047 (N-allylnormetazocine), which also resemble PCP in their ability to induce psychotomimetic behavior. The data support the idea that these three drugs act on the same receptors.

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