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Effects of phencyclidine on active avoidance and escape in rats

✍ Scribed by Parthena Martin; Michelle Manning; Carlleen Norman

Publisher: Springer
Year: 1985
Tongue: English
Weight: 347 KB
Volume: 86
Category: Article
ISSN: 0033-3158
DOI: 10.1007/bf00431717

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✦ Synopsis

Rats trained to avoid electrical shock in a shuttle box were given phencyclidine (0.0, 1.0, 5.0, or 10.0 mg/kg) prior to testing for 5 consecutive days. There was a dose-dependent increase in both avoidance and escape failures although animals continued to cross the barrier during intertrial intervals, indicating that they were capable of making the appropriate response. Little evidence of tolerance was found during the 5-day testing period.

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