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Effects of phencyclidine, haloperidol, and naloxone on fixed-interval performance in rats

✍ Scribed by George C. Wagner; David B. Masters; Arthur Tomie

Publisher: Springer
Year: 1984
Tongue: English
Weight: 709 KB
Volume: 84
Category: Article
ISSN: 0033-3158
DOI: 10.1007/bf00432020

No coin nor oath required. For personal study only.

✦ Synopsis

Phencyclidine (PCP), haloperidol, and naloxone were administered alone and in combination to rats responding under a fixed-interval schedule for water presentation. Lower doses of PCP (0.25-2.0 mg/kg) and naloxone (0.001-0.1 mg/kg) produced increases while higher doses produced dose-dependent decreases in response rate. Haloperidol (0.0625-0.5 mg/kg) produced a monotonic dose-dependent decrease in responding. When a dose of naloxone (8.0 mg/kg) that did not alter responding was administered prior to the PCP, the PCP dose-response curve was shifted to 6.5-fold lower doses of PCP. When a dose of haloperidol (0.0625 mg/kg) that did not alter responding was administered prior to the PCP, the PCP dose-response curve was shifted to 1.5-fold higher dose of PCP. These observations are discussed in relation to current views of the mechanism of PCP action.

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