The anticonvulsant activity of d-cycloserine is specific for tonic convulsions
β Scribed by Steven L. Peterson; Nathan D. Schwade
- Book ID
- 103932356
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 758 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0920-1211
No coin nor oath required. For personal study only.
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Intraventricular injection of 5,7-dihydroxytryptamine, selective destruction of descending serotoninergic neurons by 5,6-dihydroxytryptamine or electrolytic and chemical lesions of the nucleus raphe dorsalis did not affect the electroconvulsive threshold in rats. No effect was observed after the sys
This study evaluated the anticonvulsant activity of D-cycloserine against maximal electroshock seizures in rats. Systematically administered D-cycloserine (i.p.) inhibited maximal electroshock-induced tonic hindlimb extension in a dose-dependent manner with an ED50 of 153 mg/kg. No neurological defi