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The angioregulatory phenotype of native human acute myelogenous leukemia cells: influence of karyotype, Flt3 abnormalities and differentiation status

✍ Scribed by Nils Glenjen; Randi Hovland; Line Wergeland; Øystein Wendelbo; Peter Ernst; Øystein Bruserud


Book ID
114423286
Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
153 KB
Volume
71
Category
Article
ISSN
0902-4441

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## Abstract Our study explored the drug interaction of all‐__tran__s retinoic acid (ATRA) and RAD001 (everolimus), the inhibitor of mammalian target of rapamycin complex 1 (mTORC1), in acute myelogenous leukemia (AML) NB4 and HL60 cells. RAD001 (10 nM) significantly enhanced the ATRA‐induced growth