The androgen receptor in hormone-refractory prostate cancer
β Scribed by Mao, Hai-Lei; Zhu, Zhi-Qi; Chen, Charlie Degui
- Book ID
- 109832311
- Publisher
- Nature Publishing Group
- Year
- 2008
- Tongue
- English
- Weight
- 384 KB
- Volume
- 11
- Category
- Article
- ISSN
- 1008-682X
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p53 protein expression of 30 hormone-refractory locally recurrent prostate cancers was compared with their matched untreated primary tumour specimens. In addition, androgen receptor (AR) gene amplification and p53 protein immunostaining were compared. p53 positivity increased during hormonal therapy
Prostate cancer is considered to be one of the most hormone-dependent human malignancies. As a key mediator of hormonal response, the androgen receptor (AR) is believed to have an important role in the progression of prostate cancer. Mutations in the coding region of the AR gene have been found in b