The androgen receptor and signal-transduction pathways in hormone-refractory prostate cancer. Part 2: androgen-receptor cofactors and bypass pathways
β Scribed by Joanne Edwards; John M.S. Bartlett
- Book ID
- 109051821
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 404 KB
- Volume
- 95
- Category
- Article
- ISSN
- 1464-4096
No coin nor oath required. For personal study only.
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p53 protein expression of 30 hormone-refractory locally recurrent prostate cancers was compared with their matched untreated primary tumour specimens. In addition, androgen receptor (AR) gene amplification and p53 protein immunostaining were compared. p53 positivity increased during hormonal therapy
## Abstract The molecular mechanism underlying the actions of estrogens in normal prostate physiology and prostate cancer development remains unclear. In the present study we tested the hypothesis that estrogens modulate androgenβdependent events in prostate cells by examining the effects of 17Ξ²βes