The analytical control of the composition of creams

✍ Scribed by F.J. Van De Vaart; A. Hulshoff; A.W.M. Indemans

• Book ID: 103910605
• Publisher: Elsevier Science
• Year: 1983
• Tongue: English
• Weight: 594 KB
• Volume: 1
• Category: Article
• ISSN: 0731-7085
• DOI: 10.1016/0731-7085(83)80064-8

✦ Synopsis

The analysis without prior sample clean-up of promethazine hydrochloride or clioquinol in commercially available creams has been investigated using UV-spectrophotometry and titrimetric methods. The results were compared with those obtained by GLC and HPLC. Although in some cases the active drug could be determined satisfactorily using the comparatively non-selective UV-absorbance or titrimetric methods, these methods were found to be reliable only when applied to creams for which the qualitative and quantitative composition was completely known. Without prior sample clean-up, these methods will therefore be of interest mainly for process control purposes in manufacturing.