## Abstracts **Background:** Sphingosine 1โphosphate (Sphโ1โP) is a bioactive lipid mediator released from activated platelets, which regulates diverse signal transduction pathways via cell surface receptors. Recent studies have revealed that the sevenโtransmembraneโspanning receptors, Edgโ1, Edgโ3
The analysis of sphingosine 1-phosphate secretion from cells expressing Spns2
โ Scribed by Yu Hisano; Akihito Yamaguchi; Tsuyoshi Nishi
- Book ID
- 108091564
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 48 KB
- Volume
- 163
- Category
- Article
- ISSN
- 0009-3084
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Abstract G proteinโcoupled receptors (GPCRs) for lysophosphatidic acid (LPA) and sphingosine 1โphosphate (S1P) transduce signals to many functions of normal cells. Most human cancer cells upregulate S1P and LPA GPCRs, in patterns distinctive for each type of tumor. The findings that 1โalpha, 25โ
In alcoholic liver disease, ethanol-induced damage to sinusoidal endothelial cells (SECs) appears to be important in the progression of liver damage. However, little is known about the mechanisms responsible for protection of SECs against ethanol-induced injury. To elucidate the role of sphingosine