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The amino-terminally truncated forms of amyloid β-protein in brain macrophages in the ischemic lesions of Alzheimer's disease patients

✍ Scribed by Haruhiko Akiyama; Hiromi Kondo; Hiroshi Mori; Fuyuki Kametani; Toru Nishimura; Kenji Ikeda; Masanori Kato; Patrick L. McGeer


Book ID
117475113
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
557 KB
Volume
219
Category
Article
ISSN
0304-3940

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## Abstract The β‐amyloid protein (Aβ) is derived by proteolytic processing of the amyloid protein precursor (APP). Cleavage of APP by β‐secretase generates a C‐terminal fragment (APP‐CTFβ), which is subsequently cleaved by γ‐secretase to produce Aβ. Our previous studies have shown that the proteas