The amination of 3-nitro-1,5-naphthyridines by liquid ammonia/potassium permanganate. A new and convenient amination method
✍ Scribed by M. Wozniak; H. C. van der Plas; M. Tomula; A. van Veldhuizen
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 374 KB
- Volume
- 102
- Category
- Article
- ISSN
- 0165-0513
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## Abstract 3‐Nitropyridine and some of its derivatives are aminated in a liquid ammonia solution of potassium permanganate to the corresponding 2‐ and (or) 4‐ and (or) 6‐amino compounds. Quantumchemical calculations for a few 3‐nitropyridines suggest that the experimentally observed regioselectivi
## Abstract 5‐ and 6‐Nitroquinoxalines and some of their derivatives are aminated in a liquid ammonia solution of potassium permanganate to yield the corresponding 2‐ and/or 3‐ and/or 5‐amino compounds. Quantum‐chemical calculations are made to explain the regioselectivity of the amination reaction
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## Abstract Reaction of 6‐chloro‐ and 6‐(methylthio)purine with potassium amide in liquid ammonia leads to the formation of adenine. When these aminations are carried out with ^15^N‐labelled potassium amide, the ^15^N label is found to be present in the amino group, proving that these reactions do