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A new and convenient method for the amination of 1,6- and 1,7-naphthyridines using potassium amide/liquid ammonia/potassium permanganate

✍ Scribed by M. Woźniak; H. C. van der Plas; M. Tomula; A. van Veldhuizen


Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
520 KB
Volume
102
Category
Article
ISSN
0165-0513

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✍ N. J. Kos; H. C. van der Plas; A. van Veldhuizen 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 460 KB

## Abstract Reaction of 6‐chloro‐ and 6‐(methylthio)purine with potassium amide in liquid ammonia leads to the formation of adenine. When these aminations are carried out with ^15^N‐labelled potassium amide, the ^15^N label is found to be present in the amino group, proving that these reactions do