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The Alternative Pathway is Necessary and Sufficient for Complement Involvement in the Effector Phase of Anti-Collagen Antibody Induced Arthritis (ACAIA)

✍ Scribed by Nirmal Banda; Allyson Wood; Kazue Takahashi; William P. Arend; Alan Ezekowitz; V. Michael Holers


Book ID
113539929
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
42 KB
Volume
123
Category
Article
ISSN
1090-2341

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Complement activation by both classical
✍ Max Albert Hietala; Kutty S Nandakumar; Linda Persson; Susann Fahlén; Rikard Hol 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 327 KB

## Abstract To analyze the role of the classical and alternative pathways of complement activation in the effector phase of arthritis, we have induced arthritis in C3‐ and factor B (FB)‐deficient (C3^–/–^ and FB^–/–^) DBA/1J mice using well‐defined monoclonal IgG2b and IgG2a antibodies to type II c