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The alternative pathway is both necessary and sufficient for the complement-dependent injury found in the effector phase of collagen antibody induced arthritis (CAIA)

✍ Scribed by V. Michael Holers; Allyson Wood; Kazue Takahashi; Alan B. Ezekowitz; William P. Arend; Nirmal K. Banda

Book ID: 116756462
Publisher: Elsevier Science
Year: 2007
Tongue: English
Weight: 52 KB
Volume: 44
Category: Article
ISSN: 0161-5890
DOI: 10.1016/j.molimm.2007.06.016

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## Abstract To analyze the role of the classical and alternative pathways of complement activation in the effector phase of arthritis, we have induced arthritis in C3‐ and factor B (FB)‐deficient (C3^–/–^ and FB^–/–^) DBA/1J mice using well‐defined monoclonal IgG2b and IgG2a antibodies to type II c