The allele interaction between apolipoprotein ɛ2 and ɛ4 in Taiwanese Alzheimer's disease patients
✍ Scribed by F.-W. Lung; Y.-C. Yen; L.-J. Chou; C.-J. Hong; C.-K. Wu
- Book ID
- 109340755
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 105 KB
- Volume
- 111
- Category
- Article
- ISSN
- 0001-690X
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Recent studies have 'found an association between presence of apolipoprotein E (APOE) €4 allele and Alzheimer's disease (AD). The present study compared the cumulative risk of primary progressive dementia (PPD) in relatives of AD probands carrying at least one copy of the €4 allele with the relative
## Abstract Alzheimer's Disease (AD) is a complex genetic disorder with four loci already identified. Mutations in three of these, the amyloid precursor protein, presenilin I, and preseuilin II, cause early‐onset AD. The apolipoprotein E (APOE) gene contributes primarily to late‐onset AD. The APOE‐