Association between apolipoprotein E ɛ4 allele and apathy in probable Alzheimer's disease
✍ Scribed by R. Monastero; E. Mariani; C. Camarda; T. Ingegni; M. R. Averna; U. Senin; R. Camarda; P. Mecocci
- Book ID
- 109340936
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 101 KB
- Volume
- 113
- Category
- Article
- ISSN
- 0001-690X
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Recent studies have 'found an association between presence of apolipoprotein E (APOE) €4 allele and Alzheimer's disease (AD). The present study compared the cumulative risk of primary progressive dementia (PPD) in relatives of AD probands carrying at least one copy of the €4 allele with the relative
## Abstract Alzheimer's Disease (AD) is a complex genetic disorder with four loci already identified. Mutations in three of these, the amyloid precursor protein, presenilin I, and preseuilin II, cause early‐onset AD. The apolipoprotein E (APOE) gene contributes primarily to late‐onset AD. The APOE‐