The albino mutation of tyrosinase alters ocular angiogenic responsiveness
✍ Scribed by Michael S. Rogers, Irit Adini, Aaron F. McBride, Amy E. Birsner, Robert J. D’Amato
- Book ID
- 120961420
- Publisher
- Springer
- Year
- 2013
- Tongue
- English
- Weight
- 376 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0969-6970
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In the medaka fish (Oryzias latipes) many mutants for body color have been isolated. A typical example is the recessive oculocutaneous albino mutant i, which has amelanotic skin and red-colored eyes with no tyrosinase activity. To cast light on the molecular basis of the albino mechanism, we perform
Enzymatic DNA amplification and direct DNA sequencing were used to detect a mutation in the tyrosinase gene of an albino patient. Single-base change could be detected by direct sequencing. This base change (G to A) is thought to result in an amino acid change (Arg to Gln) in tyrosinase of the patien