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Phenotypic rescue of the albino mutation in the medakafish (Oryzias latipes) by a mouse tyrosinase transgene

✍ Scribed by Yasuko Hyodo-Taguchi; Christoph Winkler; Yuri Kurihara; Angelika Schartl; Manfred Schartl

Book ID
118603010
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
625 KB
Volume
68
Category
Article
ISSN
0925-4773

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Insertion of a novel transposable elemen
Insertion of a novel transposable element in the tyrosinase gene is responsible for an albino mutation in the medaka fish, Oryzias latipes
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In the medaka fish (Oryzias latipes) many mutants for body color have been isolated. A typical example is the recessive oculocutaneous albino mutant i, which has amelanotic skin and red-colored eyes with no tyrosinase activity. To cast light on the molecular basis of the albino mechanism, we perform

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Enzymatic DNA amplification and direct DNA sequencing were used to detect a mutation in the tyrosinase gene of an albino patient. Single-base change could be detected by direct sequencing. This base change (G to A) is thought to result in an amino acid change (Arg to Gln) in tyrosinase of the patien