The Akt of CD28 costimulation of T cells
β Scribed by Yoji Shimizu
- Book ID
- 117786871
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 16 KB
- Volume
- 22
- Category
- Article
- ISSN
- 1471-4906
No coin nor oath required. For personal study only.
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βͺ Abstractβ T cells play a central role in the initiation and regulation of the immune response to antigen. Both the engagement of the TCR with MHC/Ag and a second signal are needed for the complete activation of the T cell. The CD28/B7 receptor/ligand system is one of the dominant costimulatory pat
## Abstract The T cell surface protein CD28 provides a critical costimulatory signal for T cell activation. With age, humans accumulate increasing numbers of CD28^β^ T cells, and this loss of CD28 expression is exacerbated certain disease states, such as HIV infection, autoimmune conditions or canc