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The affinity, selectivity and biological activity of telenzepine enantiomers

✍ Scribed by C. Schudt; R. Boer; M. Eltze; R. Riedel; G. Grundler; N.J.M. Birdsall

Book ID
115882793
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
648 KB
Volume
165
Category
Article
ISSN
0014-2999

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## Abstract The enantiomers of 1‐methyl‐3‐(10__H__‐phenothiazine‐10‐ylmethyl)‐1‐azoniabicyclo[2,2,2]octane iodide (1) were prepared by chiral chromatographic resolution of the precursor mequitazine (2). The (+)‐(S)‐enantiomer 1b is 10‐fold more potent than (βˆ’)‐(R)‐enantiomer 1a as a histamine antag