✦ LIBER ✦

The advantages of evaporative light scattering detection in pharmaceutical analysis by high performance liquid chromatography and supercritical fluid chromatography

✍ Scribed by Lafosse, Michel ;Elfakir, Claire ;Morin-Allory, Luc ;Dreux, Michel

Publisher: John Wiley and Sons
Year: 1992
Tongue: English
Weight: 614 KB
Volume: 15
Category: Article
ISSN: 0935-6304
DOI: 10.1002/jhrc.1240150509

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The evaporative light scattering detector (ELSD) has been used in pharmaceutical analysis by liquid and supercritical fluid chromatography. An ELSD equipped with interchangeable interfaces enables the use of various eluents (UV‐ or non‐UV‐absorbing) in isocratic or gradient mode. Analyses were performed on several non‐UV‐absorbing excipients and active substances. The narrow spread of the response factors of the various compounds investigated has indicated that the detector is suitable for direct raw quantitation of unknown samples in stability studies.

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