The Adrenergic Pharmacology of Carvedilol
β Scribed by Gisbert Sponer; Giora Z. Feuerstein
- Book ID
- 110282610
- Publisher
- Springer
- Year
- 1999
- Tongue
- English
- Weight
- 127 KB
- Volume
- 4
- Category
- Article
- ISSN
- 1382-4147
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Animal work has shown that carvedilol is a nonselective beta-blocking drug. It has a vasodilator action from alpha-receptor blockade, but there is evidence that it has further action to relax smooth muscle, possibly from calcium channel antagonism. Carvedilol is lipid soluble and 25% bioavailable, a
Carvedilol, a new beta-blocker with vasodilating properties due to alpha 1-blockade, was investigated in preparations of human ventricular myocardium. Carvedilol demonstrated a high affinity and is a slightly beta 1-selective competitive beta-blocking agent, with a KD for beta 1-receptors of approxi