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The Adrenergic Pharmacology of Carvedilol

✍ Scribed by Gisbert Sponer; Giora Z. Feuerstein


Book ID
110282610
Publisher
Springer
Year
1999
Tongue
English
Weight
127 KB
Volume
4
Category
Article
ISSN
1382-4147

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πŸ“œ SIMILAR VOLUMES


The pharmacology of carvedilol
✍ R. R. Ruffolo; M. Gellai; J. P. Hieble; R. N. Willette; A. J. Nichols πŸ“‚ Article πŸ“… 1990 πŸ› Springer 🌐 English βš– 616 KB
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✍ Tomlinson, B. ;Prichard, B.N.C. ;Graham, B.R. ;Walden, R.J. πŸ“‚ Article πŸ“… 1992 πŸ› Springer-Verlag 🌐 English βš– 922 KB

Animal work has shown that carvedilol is a nonselective beta-blocking drug. It has a vasodilator action from alpha-receptor blockade, but there is evidence that it has further action to relax smooth muscle, possibly from calcium channel antagonism. Carvedilol is lipid soluble and 25% bioavailable, a

Effects of carvedilol on adrenergic rece
✍ Bristow, M.R. ;Larrabee, P. ;MοΏ½ller-Beckmann, B. ;Minobe, W. ;Roden, R. ;Skerl, πŸ“‚ Article πŸ“… 1992 πŸ› Springer-Verlag 🌐 English βš– 778 KB

Carvedilol, a new beta-blocker with vasodilating properties due to alpha 1-blockade, was investigated in preparations of human ventricular myocardium. Carvedilol demonstrated a high affinity and is a slightly beta 1-selective competitive beta-blocking agent, with a KD for beta 1-receptors of approxi