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Pharmacology of carvedilol

✍ Scribed by Brian Dulin; William T Abraham

Book ID
118415503
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
224 KB
Volume
93
Category
Article
ISSN
0002-9149

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Animal work has shown that carvedilol is a nonselective beta-blocking drug. It has a vasodilator action from alpha-receptor blockade, but there is evidence that it has further action to relax smooth muscle, possibly from calcium channel antagonism. Carvedilol is lipid soluble and 25% bioavailable, a

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Carvedilol, a new beta-blocker with vasodilating properties due to alpha 1-blockade, was investigated in preparations of human ventricular myocardium. Carvedilol demonstrated a high affinity and is a slightly beta 1-selective competitive beta-blocking agent, with a KD for beta 1-receptors of approxi