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The activity of Catechol-O-Methyltransferase in parkinsonian patients with "on-off fluctuations"

✍ Scribed by D. Woitalla; R. Karwasz; Th. Müller; H. Przuntek; W. Kuhn

Book ID: 106208015
Publisher: Springer
Year: 2000
Tongue: English
Weight: 66 KB
Volume: 107
Category: Article
ISSN: 1435-1463
DOI: 10.1007/s007020050009

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## Abstract Soman (pinacolyl methylphosphonofluoridate) not only increases acetylcholine levels by inhibiting cholinesterases, it also alters the levels of some other neurotransmitters including norepinephrine, dopamine, and serotonin. Soman also causes an alteration in the activities of the enzyme