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The action of the Notch locus in Drosophila melanogaster

✍ Scribed by Thörig, G. E. W. ;Heinstra, P. W. H. ;Scharloo, W.

Publisher
Springer
Year
1981
Tongue
English
Weight
705 KB
Volume
182
Category
Article
ISSN
0026-8925

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✦ Synopsis

It is shown that the Notch 8 deficiency in Drosophila melanogaster affects a number of enzyme activities localized in the mitochondria, such as NADH oxidase (activity of the complete respiratory chain), NADH dehydrogenase (the first step in the respiratory chain before transfer to ubiquinone), Succinate dehydrogenase and ~-Glycerophosphate dehydrogenase. The experiments reported here do not exclude the possibility of involvement of other genes in the deficiency. The effect of duplications of the Notch locus on NADH oxidase and NADH dehydrogenase suggest that this locus determines the enzyme activities.

The dosage effects of the Notch locus on activity suggest that this locus contains the structural genes for these enzymes.

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