The action of six antagonists of the excitatory amino acids on neurones of the rat spinal cord

✍ Scribed by H. McLennan; Jin-rong Liu

• Publisher: Springer-Verlag
• Year: 1982
• Tongue: English
• Weight: 535 KB
• Volume: 45-45
• Category: Article
• ISSN: 0014-4819
• DOI: 10.1007/bf00235774

✦ Synopsis

The differential susceptibility to blockade by six antagonists of the excitatory actions produced by a number of acidic amino acids has been determined. Four of these, DL-alpha-aminoadipate, 2-amino-5-phosphonovalerate, 2-amino-6-phosphonocaproate and gamma-D-glutamylglycine block the action of N-methyl-D-aspartate (NMDA) most effectively and those of L-glutamate, trans-1-amino-1,3-dicarboxycyclopentane (trans-ADCP) and kainate the least. Cis-2,3-piperidine dicarboxylate resembles the other four, save in that kainate excitations are also powerfully blocked. L-glutamate diethylester was most effective against L-glutamate and least against NMDA: kainate and trans-ADCP excitations were also relatively unaffected. The data support the hypothesis of the existence of at least three classes of amino acid receptor (NMDA-, L-glutamate- and kainate-excited), and the possibility of a fourth category activated by trans-ADCP must be considered.