The Absolute Configuration of the Glutarimide Antibiotics Streptimidone and 9-Methylstreptimidone
β Scribed by Anna Maria Becker; Rodney W. Rickards
- Book ID
- 102857796
- Publisher
- John Wiley and Sons
- Year
- 1976
- Tongue
- German
- Weight
- 670 KB
- Volume
- 59
- Category
- Article
- ISSN
- 0018-019X
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β¦ Synopsis
Abstract
Chemical and spectroscopic studies have established the absolute configuration of the glutarimide antibiotics streptimidone and 9βmethylstreptimidone, which can now be represented as the (2__R__,5__S__,6__E__)βstructures 14 and 15, respectively.
π SIMILAR VOLUMES
The crystal structure of the antibiotic hedamycin (1) has been solved by direct method and refined by least squares techniques to R=0.091 for 2289 of 2643 independent reflexions. Crystals of C4,HS,,N,0 are orthorhombic, space group P2,2,2' with lattice parameters a=24.239 (12), b=21.440 (lo), c=7.36
As a result of the x-ray single crystal analysis of N-iodoacetylamphotericin B the chemical and stereochemical absolute structure ia presented (I). A similar etructure and stereochemistry wae extended to the parent compound itself, amphotericin B, a heptaene macrolide antifungal antibiotic possessin
Tetrahedron Letters No. 41. pp. 3601-3604 (1970) p. 3529 W. Sprenger was omitted from the "Contributors to this issue" W. MECHLINSKI, C. P. SCHAFFNER, P. GANIS and G. AVITABILE: Structure and absolute configuration of the polyene macrolide antibiotic amphotericin B.