The absolute configuration of chiral organophosphorus anticholinesterases
โ Scribed by H.P. Benschop
- Book ID
- 119026725
- Publisher
- Elsevier Science
- Year
- 1975
- Tongue
- English
- Weight
- 131 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0048-3575
No coin nor oath required. For personal study only.
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By the spontaneous resolution of racemic compound 1,8-bis(dimethylamino)-2-( -hydroxy--phenylethyl)naphthalene (ยฑ)-1, enantiomer (-)-1 was obtained; its treatment with C 5 H 5 NโขHBr resulted in the formation of proton sponge (-)-2; the absolute configurations of (R)-(-)-2 and, as a consequence, (R)-
Sutmnary: Absolute configurations of axially chiral biaryls with hydroxyl, amino, and carboxyl groups can be easily determined by pmr spectra using MTPA derivatives and shift reagents. Recently chiral biaryls have been successfully utilized in the field of asynetric synthesis\*. For example, virtual