Absolute configuration of chiral polar crystals
โ Scribed by Berkovitch-Yellin, Z.; Addadi, L.; Idelson, M.; Leiserowitz, L.; Lahav, M.
- Book ID
- 109725713
- Publisher
- Nature Publishing Group
- Year
- 1982
- Tongue
- English
- Weight
- 739 KB
- Volume
- 296
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/296027a0
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By the spontaneous resolution of racemic compound 1,8-bis(dimethylamino)-2-( -hydroxy--phenylethyl)naphthalene (ยฑ)-1, enantiomer (-)-1 was obtained; its treatment with C 5 H 5 NโขHBr resulted in the formation of proton sponge (-)-2; the absolute configurations of (R)-(-)-2 and, as a consequence, (R)-
Sutmnary: Absolute configurations of axially chiral biaryls with hydroxyl, amino, and carboxyl groups can be easily determined by pmr spectra using MTPA derivatives and shift reagents. Recently chiral biaryls have been successfully utilized in the field of asynetric synthesis\*. For example, virtual