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The absolute bioavailability of clodronate from two different oral doses

✍ Scribed by K Villikka; K Perttunen; J Rosnell; H Ikvalko; H Vaho; L Pylkknen


Book ID
117807717
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
58 KB
Volume
31
Category
Article
ISSN
8756-3282

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A method to quantitate N-acetylcysteine in plasma using reductive cleavage with tributylphosphine and post-HPLC column derivatisation with o-phthalaldehyde is described. Using this method, endogenous average concentrations of 0.08 jtM were measured in 10 volunteers participating in a crossover study