The 4-[ N -Methyl- N -(2,2,2-trifluoroacetyl)amino]butyl Group as an Alternative to the 2-Cyanoethyl Group for Phosphate Protection in the Synthesis of Oligodeoxyribonucleotides
β Scribed by Wilk, Andrzej; Grajkowski, Andrzej; Phillips, Lawrence R.; Beaucage, Serge L.
- Book ID
- 127287909
- Publisher
- American Chemical Society
- Year
- 1999
- Tongue
- English
- Weight
- 118 KB
- Volume
- 64
- Category
- Article
- ISSN
- 0022-3263
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π SIMILAR VOLUMES
## Abstract The free energy of activation for rotation about the exocyclic Cο£ΏN bond of the dimethylamino group of some 6βsubstituted 2βaminoβ4β(__N__,__N__βdimethylamino)pyrmidines has been determined using ^1^H NMR line shape analysis. The results are discussed in terms of the relative electronβwi
2,4,5-Tribromo-l-vinylimidazole was prepared from 2,4,5-tribromoimidazole and 1,2-dibromoethane and its Br-atoms were replaced regio~lectively in the order 2 --) 5 ---> 4 via Br --~ MgBr and other exchange reactions. Efficient removal of the vinyl groups from the resulting polyfunctionalized imidazo