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Barriers to rotation of the dimethylamino group in some 2-amino-4-(N,N-dimethylamino)pyrimidines

✍ Scribed by C. H. J. Wells

Publisher: John Wiley and Sons
Year: 1982
Tongue: English
Weight: 171 KB
Volume: 20
Category: Article
ISSN: 0749-1581
DOI: 10.1002/mrc.1270200416

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✦ Synopsis

Abstract

The free energy of activation for rotation about the exocyclic CN bond of the dimethylamino group of some 6‐substituted 2‐amino‐4‐(N,N‐dimethylamino)pyrmidines has been determined using ^1^H NMR line shape analysis. The results are discussed in terms of the relative electron‐withdrawing and electron‐releasing effects of the substituents.

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