𝔖 Bobbio Scriptorium
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The 2-(methylthiomethoxy)ethoxycarbonyl [mtmec] protecting group

✍ Scribed by Simon S. Jones; Colin B. Reese; Samson Sibanda

Book ID
104241677
Publisher
Elsevier Science
Year
1981
Tongue
French
Weight
287 KB
Volume
22
Category
Article
ISSN
0040-4039

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✦ Synopsis

Alcohols (ROH) may be converted into their MTMEC deri_vatives (6) by acylation with 2-(methylthiomethoxyJethoxycarbony1 chloride (2); the MTMEC "protected protecting group" may be removed by treatment first with Hg(I1) perchlorate in the presence of 2,4,6-collidine or pyridine in acetone-water solution, followed by hydrolysis under very mild basic conditions.

A need has arisen in connection with our work on the synthesis of oligonucleotides' for acyl protecting groups which are removable under very mild basic conditions.

πŸ“œ SIMILAR VOLUMES

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