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The −1195G allele increases the transcriptional activity of cyclooxygenase-2 gene (COX-2) in colon cancer cell lines

✍ Scribed by Pereira, Carina; Sousa, Hugo; Silva, Joana; Brandão, Carla; Elgueta-Karstegl, Claudio; Farrell, Paul J.; Medeiros, Rui; Dinis-Ribeiro, Mário

Book ID
120478936
Publisher
John Wiley and Sons
Year
2013
Tongue
English
Weight
80 KB
Volume
53
Category
Article
ISSN
0899-1987

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## Abstract The overexpression of cyclooxygenase‐2 (COX‐2) and inducible nitric oxide synthase (iNOS) has been previously reported in head and neck squamous cell carcinoma (HNSCC), as well as in many cancers. We hypothesized that endogenous nitric oxide (NO) might increase the expression of COX‐2 i