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Th1/Th2 xenogenic antibody responses are associated with recipient dendritic cells

✍ Scribed by Nobuyuki Kanai; Wei-Ping Min; Thomas E. Ichim; Hao Wang; Robert Zhong

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
242 KB
Volume
27
Category
Article
ISSN
0738-1085

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✦ Synopsis

Abstract

We characterized dendritic cells (DC) phenotypically and functionally between C57BL/6 (Th1‐prone) and BALB/c (Th2‐prone) mouse recipients in an in vivo sensitization model. Two strains of mice were presensitized with Lewis rat splenocytes as xenogeneic antigens. We found that BALB/c recipients mounted a significantly higher total IgG response to the xeno‐antigens when compared with C57BL/6 recipients, 10 days after rat splenocyte infusion. A Th2‐mediated antibody response with high ratio of IgG1/IgG2a was seen in the BALB/c recipients, while a Th1 antibody response with low ratio of IgG1/IgG2a was detected in C57BL/6 recipients. CD11c^+^DC isolated from C57BL/6 recipients possessed increased expression of CD8α^+^ (DC‐1 type). The administration of bone marrow derived‐DC from IL‐12 knockout mice into C57BL/6 recipients induced a shift of Th‐mediated anti‐xenogeneic antibody responses from Th1 to Th2 domain. Our findings suggest that DC could play an important role to regulate the balance of Th1/Th2 cytokine profiles and rejection patterns in xenotransplantation. © 2007 Wiley‐Liss, Inc. Microsurgery 2007.

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