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TGF-β: the missing link in CD4+CD25+ regulatory T cell-mediated immunosuppression

✍ Scribed by WanJun Chen; Sharon M Wahl


Book ID
117757698
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
200 KB
Volume
14
Category
Article
ISSN
1359-6101

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Distinct roles of CTLA-4 and TGF-β in CD
✍ Qizhi Tang; Elisa K. Boden; Kammi J. Henriksen; Helene Bour-Jordan; Mingying Bi; 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 218 KB

## Abstract Both CTLA‐4 and TGF‐β have been implicated in suppression by CD4^+^CD25^+^ regulatory T cells (Treg). In this study, the relationship between CTLA‐4 and TGF‐β in Treg function was examined. Blocking CTLA‐4 on wild‐type Treg abrogated their suppressive activity __in vitro__, whereas neut