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TGF-β is not involved in early phase growth inhibition of keratinocytes by 1α,25(OH)2vitamin D3

✍ Scribed by Shirakata, Yuji; Ueno, Hikaru; Hanakawa, Yasushi; Kameda, Kenji; Yamasaki, Kenshi; Tokumaru, Sho; Yahata, Yoko; Tohyama, Mikiko; Sayama, Koji; Hashimoto, Koji


Book ID
119292962
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
302 KB
Volume
36
Category
Article
ISSN
0923-1811

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## Abstract 1α,25‐Dihydroxyvitamin D~3~ [1α,25(OH)~2~D~3~], the hormonally active form of vitamin D~3~, has been shown to be a potent negative growth regulator of breast cancer cells both in vitro and in vivo. 1α,25(OH)~2~D~3~ acts through two different mechanisms. In addition to regulating gene tr