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TGF-β Induced G1 Cell Cycle Arrest Requires the Activity of the Proteasome Pathway

✍ Scribed by Fan Zhang; Mia Mönkkönen; Stina Roth; Marikki Laiho

Book ID
115604420
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
205 KB
Volume
281
Category
Article
ISSN
0014-4827

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## Transforming growth factor-␤1 (TGF-␤) inhibits cell-cycle progression of many types of cells by arresting them in G 1 /S phase through inhibition of the active cyclin-Cdk complexes that lead to inhibition of Rb phosphorylation. In gastriccancer cells, SNU16, TGF-␤ treatment induced enhanced exp