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TGF-β-induced Foxp3+ regulatory T cells rescue scurfy mice

✍ Scribed by Eva N. Huter; George A. Punkosdy; Deborah D. Glass; Lily I. Cheng; Jerrold M. Ward; Ethan M. Shevach

Book ID: 102163326
Publisher: John Wiley and Sons
Year: 2008
Tongue: English
Weight: 373 KB
Volume: 38
Category: Article
ISSN: 0014-2980
DOI: 10.1002/eji.200838346

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## Abstract Scurfy mice have a deletion in the forkhead domain of the forkhead transcription factor p3 (Foxp3), fail to develop thymic‐derived, naturally occurring Foxp3^+^ regulatory T cells (nTreg), and develop a fatal lymphoproliferative syndrome with multi‐organ inflammation. Transfer of thymic

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