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TGF-β-induced CD4+Foxp3+ Cells but not Natural CD4+CD25+ Cells Suppress Established Collagen-induced Arthritis

✍ Scribed by Song Guo Zheng; Ning Kong; Xiaohui Zhou; Julie Wang; Hejian Zou; Zhongmin Liu; David Brand


Book ID
113541477
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
44 KB
Volume
135
Category
Article
ISSN
1090-2341

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## Abstract Interleukin‐2 (IL‐2) treatment is currently used to enhance T cell‐mediated immune responses against tumors or in viral infections. At the same time, IL‐2 is essential for the peripheral homeostasis of CD4^+^CD25^+^Foxp3^+^ regulatory T cells (Treg). In our study, we show that IL‐2 is a