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TGF-β differentially regulates type IV and type I collagen synthesis in rabbit proximal tubule cells

✍ Scribed by Haralson, M.A.; Goins, R.A.; DiMari, S.J.; Harris, R.C.

Book ID
122442780
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
214 KB
Volume
14
Category
Article
ISSN
0945-053X

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## Abstract Human proximal tubule (HK‐2) cells are commonly used as cellular models to understand the mechanism by which inflammatory mediators cause renal injury. It has been observed that thrombin stimulates the expression of TGF‐β, extracellular matrix (ECM) proteins and proinflammatory cytokine