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W1180 Endogenous IGFBP-3 Activates TGF-β Receptors and Regulates Type I Collagen Expression and Production in Human Intestinal Smooth Muscle Cells in Crohn's Disease

✍ Scribed by Flynn, Robert S.; Bowers, Jennifer G.; Kuemmerle, John F.

Book ID: 123278932
Publisher: Elsevier Science
Year: 2008
Tongue: English
Weight: 75 KB
Volume: 134
Category: Article
ISSN: 0016-5085
DOI: 10.1016/S0016-5085(08)63032-2

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Background: Stricture formation occurs in %30% of patients with Crohn's disease (CD) and is a significant cause of morbidity. Strictures are characterized by intestinal smooth muscle cell hyperplasia, smooth muscle cell hypertrophy, and fibrosis due to excess net extracellular matrix production, inc