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TGF-β-activated kinase 1 mediates mechanical stress-induced IL-6 expression in osteoblasts

✍ Scribed by Naoto Fukuno; Hiroyuki Matsui; Yoshiaki Kanda; Osamu Suzuki; Kunihiro Matsumoto; Keiichi Sasaki; Takayasu Kobayashi; Shinri Tamura

Book ID: 116301514
Publisher: Elsevier Science
Year: 2011
Tongue: English
Weight: 554 KB
Volume: 408
Category: Article
ISSN: 0006-291X
DOI: 10.1016/j.bbrc.2011.02.127

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We investigated the regulatory mechanism of interleukin-6 (IL-6) synthesis induced by interleukin-1 (IL-1) in osteoblast-like MC3T3-E1 cells. IL-1 stimulated the secretion of IL-6 in a dose-dependent manner in the range between 0.1 and 100 ng/ml. Staurosporine and calphostin C, inhibitors of protein