TfOH/C-catalyzed one-pot three-component synthesis ofα-amino phosphonates under solvent-free conditions
✍ Scribed by Jafari, Abbas Ali; Amini, Sakineh; Tamaddon, Fatemeh
- Book ID
- 120500898
- Publisher
- Iranian Chemical Society
- Year
- 2013
- Tongue
- English
- Weight
- 302 KB
- Volume
- 10
- Category
- Article
- ISSN
- 1735-207X
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## Abstract Uncatalyzed one‐pot, three‐component reactions of aldehydes, chiral α‐methylamines, and dimethyl phosphite under solvent‐free conditions were used for the diastereoselective synthesis of α‐amino phosphonates. The reactions proceeded with extremely high efficiency under mild conditions a
A simple, efficient, and environmentally benign method for a three-component reaction of an amine, an aldehyde or a ketone, and diethyl phosphite catalyzed by Amberlite-IR 120 resin has been developed to afford a-amino phosphonates in high yields and short reaction times under solvent-free reaction