Tetrodotoxin blocks HIV coat protein (gp120) toxicity in primary neuronal cultures
β Scribed by Diop, A.G.; Lesort, M.; Esclaire, F.; Sindou, P.; Couratier, P.; Hugon, J.
- Book ID
- 122070717
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 482 KB
- Volume
- 165
- Category
- Article
- ISSN
- 0304-3940
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HIV-l-associated cognitive/motor complex is one of the major neurological complications of AIDS and is associated with neuronal loss. Gp120, the HIV envelope protein, is toxic for neurons in cultures and produces a rise in intracytosolic calcium. This neurotoxicity is dose-dependent and time-depende
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