Tetrodotoxin and saxitoxin, and the sodium channels of excitable tissue
β Scribed by J.M. Ritchie
- Book ID
- 119110530
- Publisher
- Elsevier Science
- Year
- 1980
- Tongue
- English
- Weight
- 643 KB
- Volume
- 1
- Category
- Article
- ISSN
- 0165-6147
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π SIMILAR VOLUMES
Voltage clamp experiments were done on single myelinated frog nerve fibres. The rate of block of Na + channels by tetrodotoxin (TTX) was obtained from changes in peak Na + current during 1-Hz trains of depolarizing impulses. In hypertonic Na+-rich solution (216 raM) the stationary block was reduced
Na currents and Na-current fluctuations were measured in myelinated frog nerve fibres to study interactions between monovalent externally applied cations and the binding of the Na-channel blockers tetrodotoxin (TTX) or saxitoxin (STX). Adding ll0mM NaC1 to Ringer's solution increased the maximum pea