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Mapping the site of block by tetrodotoxin and saxitoxin of sodium channel II

✍ Scribed by Heinrich Terlau; Stefan H. Heinemann; Walter Stühmer; Michael Pusch; Franco Conti; Keiji Imoto; Shosaku Numa

Book ID
115925423
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
428 KB
Volume
293
Category
Article
ISSN
0014-5793

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Influence of Na+and Li+ions on the kinet
Influence of Na+and Li+ions on the kinetics of sodium channel block by tetrodotoxin and saxitoxin
✍ G. Hansen; W. Ulbricht 📂 Article 📅 1991 🏛 Springer 🌐 English ⚖ 826 KB

Voltage clamp experiments were done on single myelinated frog nerve fibres. The rate of block of Na + channels by tetrodotoxin (TTX) was obtained from changes in peak Na + current during 1-Hz trains of depolarizing impulses. In hypertonic Na+-rich solution (216 raM) the stationary block was reduced