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Tetrazole analogues of cyclolinopeptide A: Synthesis, conformation, and biology

✍ Scribed by Krzysztof Kaczmarek; Stefan Jankowski; Ignacy Z. Siemion; Zbigniew Wieczorek; Ettore Benedetti; Paola Di Lello; Carla Isernia; Michele Saviano; Janusz Zabrocki


Publisher
Wiley (John Wiley & Sons)
Year
2002
Tongue
English
Weight
258 KB
Volume
63
Category
Article
ISSN
0006-3525

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πŸ“œ SIMILAR VOLUMES


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## SYNOPSIS CD and nmr techniques have been used to study, in acetonitrile solution, the ion-complexing capability of cyclolinopeptide A (CLA) , a cyclic nonapeptide of sequence cyclo-( Pro-Pro-Phe-Phe-Leu-Ile-Ile-Leu-Val) endowed with remarkable cytoprotective ability in vitro, and the conformati

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## Abstract Starting with the ω‐hydroxy and ω‐amino acid derivatives **13** and **21**, the two closely related geodiamolide analogs **32** and **35**, respectively, were prepared. Compared to the natural cyclodepsipeptide geodiamolide (**1**), the macrocycles **32** and **35** have a smaller ring

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A mono-proline analogue of the potent anthelmintic cyclooctadepsipeptide PF1022A has been synthesized. NMR studies in combination with molecular dynamics simulations demonstrate that the conΓΌrmation of this analogue is both rigidiΓΌed and distorted compared with the asymmetric conformation of PF1022A