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Tetraploid acute promyelocytic leukemia with double t(15;17) and PML/RARA rearrangements detected by fluorescence in situ hybridization analysis

✍ Scribed by Seung Hwan Oh; Tae Sung Park; Hyung Hoi Kim; Chulhun L. Chang; Eun Yup Lee; Han Chul Son; Joo Seop Chung; Goon Jae Cho

Book ID
114135604
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
285 KB
Volume
145
Category
Article
ISSN
0165-4608

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## Abstract We compared genomic breakpoints at the __PML__ and __RARA__ loci in 23 patients with therapy‐related acute promyelocytic leukemia (t‐APL) and 25 de novo APL cases.Eighteen of 23 t‐APL cases received the topoisomerase II poison mitoxantrone for their primary disorder. DNA breaks were clu