Tetrapetalone A, a novel lipoxygenase inhibitor from Streptomyces sp.

✍ Scribed by Toshikazu Komoda; Yasumasa Sugiyama; Naoki Abe; Misako Imachi; Hiroshi Hirota; Akira Hirota

• Publisher: Elsevier Science
• Year: 2003
• Tongue: French
• Weight: 179 KB
• Volume: 44
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(03)00007-8

✦ Synopsis

Tetrapetalone A (I), C 26 H 33 O 7 N, is a novel lipoxygenase inhibitor isolated from a culture filtrate of Streptomyces sp. USF-4727 strain. Its chemical structure was determined by its spectroscopic evidence and methylation with diazomethane. The stereochemistry was investigated by the coupling constant in 1 H NMR, NOESY data and modified Mosher's method. I possessed a tetracyclic skeleton and a b-rhodinosyl moiety, and this is the first report of a compound with such a tetracyclic skeleton.